What is a common adverse reaction of rifampin?

Rifampin is an antibiotic commonly used to treat tuberculosis and certain other bacterial infections. One well-known adverse reaction associated with rifampin is the harmless red-orange discoloration of bodily fluids, including urine, saliva, sweat, and tears. This occurs because rifampin is excreted in these fluids and is due to the drug's chromophoric properties, which do not indicate toxicity or harm to the patient.

Understanding this side effect is important for both patients and healthcare providers, as the discoloration may cause concern but does not require discontinuation of the medication or further medical intervention. Patients should be informed about this effect before starting treatment to avoid unnecessary anxiety. Recognizing that this discoloration is harmless enables patients to continue their treatment regimen without fear of adverse effects related to the color changes in their bodily fluids.