Henry Ford Pharmacology Practice Test

Acetylsalicylic acid, commonly known as aspirin, can cause gastric irritation and increase the risk of gastrointestinal side effects, including ulcers and bleeding. To minimize this risk, it is recommended that patients take acetylsalicylic acid with food or milk.

Taking the medication with food or milk serves several purposes. First, food can act as a protective barrier in the stomach, reducing direct contact between the drug and the gastric mucosa. This helps to buffer the stomach lining against irritation. Additionally, milk provides a soothing coating effect and may help neutralize stomach acid, further decreasing the potential for irritation.

In contrast, taking acetylsalicylic acid on an empty stomach can increase the likelihood of discomfort and gastrointestinal distress, as there is less protective material present to buffer the stomach. Additionally, using hot water or taking it after meals does not offer the same protective benefits that food or milk provides, thereby missing an opportunity to reduce the risk of gastric irritation.