What common side effect is associated with tricyclic antidepressants?

Tricyclic antidepressants (TCAs) are known to have a range of side effects due to their mechanism of action, which involves blocking the reuptake of neurotransmitters such as norepinephrine and serotonin. One of the most frequently reported side effects of TCAs is dry mouth, also known as xerostomia. This occurs because these medications can inhibit the effects of the neurotransmitter acetylcholine, which is involved in stimulating saliva production. The anticholinergic effects of TCAs contribute significantly to this side effect.

Although increased appetite, ringing in the ears, and weight loss can occur in certain situations, they are not as commonly associated with tricyclic antidepressants as dry mouth. Increased appetite may occur with some antidepressants but is more characteristic of other classes, while weight loss typically happens less frequently with TCAs. Ringing in the ears, or tinnitus, is not a well-documented side effect linked to this class of drugs. Thus, dry mouth stands out as a classic and common side effect observed in patients taking tricyclic antidepressants.