What is the "rebound effect" in pharmacology?

The "rebound effect" in pharmacology refers to a phenomenon where symptoms that were previously managed or alleviated by a medication return, often at a more intense level, after the drug is discontinued. This is particularly common in certain classes of medications, such as benzodiazepines or corticosteroids. When patients stop these drugs abruptly, they may experience a resurgence of the original symptoms that can be more severe than what they initially experienced before starting treatment. This effect underscores the importance of carefully managing drug withdrawal and tapering doses under medical supervision to avoid a worsening of symptoms.